Green Chemistry Approaches to Pharmaceutical Waste Reduction: Innovative Solvent Systems and Process Optimization
Engy Soliman
Co-Presenters: Individual Presentation
College: The Dorothy and George Hennings College of Science, Mathematics and Technology
Major: Chemistry
Faculty Research Mentor: Heather Stokes-Huby
Abstract:
PURPOSEThe pharmaceutical industry's environmental impact through waste generation presents a significant challenge in modern manufacturing processes. The current paper aims to explore the theme of green chemistry solutions for managing pharmaceutical waste through novel solvents and process improvement methods. The purpose of the research is to compare effectiveness of other solvents for the treatment in the overall waste reduction as well as improving the manufacturing processes.METHODSThe study uses two major approaches; these are, the use of non-conventional solvents and optimization techniques. The objectives of the study are to evaluate the utility of deep eutectic solvents and bio based solvents as green solvents in synthesizing pharmaceutical products. In addition, the work highlights the process intensification concepts as well as continuous flow reactions and processes for reduction of waste. The investigation encompasses both laboratory-scale innovations and their potential industrial applications, with particular attention to scalability and economic viability.SIGNIFICANCE/NOVELTYThis research contributes significantly to advancing sustainable practices in pharmaceutical manufacturing by providing a comprehensive analysis of innovative waste reduction strategies. The results provide useful recommendations for the various drug makers who wish to minimize their impact on the environment without compromising their productivity. The integration of different classes of solvents with process optimization methods makes this study a guide to the future advancements in green chemical synthesis. These findings have significant implications for the industry practitioners and researchers who are striving for better sustainable strategies in the manufacturing of pharmaceuticals and can pave the way for the future changes.CONCLUSIONThe study establishes that it is possible to reduce pharmaceutical manufacturing waste by adopting other types of solvents and the right processes. Deep eutectic solvents and bio-solvents can decrease the environmental detriment by as much as 50% in comparison with conventional organic solvents. Continuous flow chemistry and process intensification concepts can reduce waste by up to 60 percent while improving productivity. The integration of these strategies represents a promising avenue toward making pharmaceutical manufacturing less dependent on the environment.Keywords: green chemistry, pharmaceutical waste reduction, sustainable manufacturing, solvent systems, process optimization