Non-Opioid Pain Management: Drugs Targeting Selective Sodium Channels
Molly Buchberger
Co-Presenters: Individual Presentation
College: The Dorothy and George Hennings College of Science, Mathematics and Technology
Major: Chemistry
Faculty Research Mentor: Matthew Mongelli
Abstract:
TITLENon-Opioid Pain Management: Drugs Targeting Selective Sodium ChannelsINTRODUCTIONThe increasing prevalence of opioid addiction highlights the urgent need for alternative painmanagement strategies that minimize the risk of dependency. This paper explores the role ofselective sodium channel inhibitors in the development of non-opioid pain treatments. Sodiumchannels are essential for transmitting pain signals, and targeting specific sodium channelsubtypes offers a promising approach to pain relief. By blocking pain signal transmission inperipheral nerves, sodium channel inhibitors provide an alternative mechanism to opioids,potentially offering safer and more effective treatment options for patients with pain.METHODSThis study is a comprehensive review of peer-reviewed journal articles and clinical studiesfocused on sodium channel inhibition in pain management.CONCLUSIONSelective sodium channel inhibition is a viable non-opioid approach for managing pain andresearch indicates that these inhibitors can effectively block pain signaling with fewer sideeffects and lower risk of addiction than opioids. Further research and innovation in this areamay lead to novel, non-addictive pain relief solutions for patients in need.SIGNIFICANCEThis paper highlights the potential of selective sodium channel inhibitors as a groundbreakingalternative to opioid analgesics. By targeting specific sodium channel subtypes, these drugsoffer a precise mechanism for pain relief, reducing the risk of addiction and other side effects.As research advances, the development of more selective and effective sodium channelinhibitor drugs could transform pain management and contribute to addressing the ongoingopioid crisis.